apalutamide will lessen the extent or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication that happen to be CYP3A4 substrates may result in reduced publicity to those medicines.Talk to your health practi